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The New Alkaloids from Antidesma cuspidatum M.A.

Berna Elya, Roshamur C. Forestrania, Mat Ropi, Soleh Kosela, Khalijah Awang, Hanita Omar and A. Hamid A. Hadi

Faculty of Pharmacy, University of Indonesia, Kampus UI Depok 16424, Indonesia

Department of Chemistry, University Malaya, Kuala Lumpur, Malaysia

Department of Chemistry, University of Indonesia, Kampus UI Depok 16424, Indonesia

Abstract: Two new alkaloids, cuspidatin (1) and cuspidatinol (2), were isolated from Antidesma cuspidatum M.A. (Euphorbiaceae). The structures were determined by means of spectroscopic analysis (IR, MS, and NMR spectroscopy). The results of cytotoxicity evaluation showed that compounds 1 and 2 were inhibitory to L1210 cells, with IC 50 values 8.41 and 6.36 µg/mL respectively.

Keywords: Antidesma cuspidatum M.A.; Alkaloids; Euphorbiaceae; Cytotoxic activity. © 2014 ACG Publications. All rights reserved.