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Antioxidant Activities of Chemical Constituents Isolated from Echinops orientalis Trauv.

Ramazan Erenler, Sakine Yilmaz, Huseyin Aksit, Ozkan Sen, Nusret Genc, Mahfuz Elmastas and Ibrahim Demirtas

Department of Chemistry, Faculty of Art and Science, Gaziosmanpasa University, Taslıciftlik Campus, 60240 Tokat, Türkiye

Department of Chemistry, Faculty of Science, Cankiri Karatekin University, Ballica Campus, 18100 Cankiri, Türkiye

Abstract: The genus Echinops belonging to the Asteraceae family comprises 130 species. The dried leaves and seeds of Echinops orientalis Trauv. were extracted separately with methanol. Apigenin-7-O-(6"-trans-p-coumaroyl- b -D-glucopyranoside 1, and Apigenin-7-O- b -D glucoside 2 were isolated from leaves and 1-methoxycarbonylindole 3 and beta-sitositerol 4 were isolated from seeds. The compounds were isolated by chromatographic techniques, based on column chromatography, preparative TLC and identified by spectroscopic methods including 1D-, 2D-NMR, UV, IR, HPLC-QTOF/MS. Isolated compounds and extracts were applied to antioxidant activity tests. While s eeds and leaves extracts have high DPPH and moderate ABTS radical scavenging activities, the isolated flavones exhibited high cation radical scavenging activities.

Keywords:Echinops orientalis Trauv.; flavonoids; quinoline; antioxidant activities .

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