Isolation, Structure Determination, In Vivo/Vitro Assay and Docking Study of a Xanthone with antitumor activity from Fungus Penicillium oxalicum
Gang Chen, Zhe Jiang, Jiao Bai, Haifeng Wang, Shuling Zhang and Yuehu Pei
1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
2 Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical
University), Ministry of Education, Shenyang 110016, China
3 Department of Pharmacy, Yanbian University Hospital, Yanji, 133000, China
4 Division of Oncology, Shengjing Hospital of China Medical University, Shenyang, 110004, China
Abstract: Investigation of EtOAc extract from the fermentation broth of the fungus Penicillium oxalicum led to the isolation of a xanthone, secalonic acid D, which showed good antitumor activity both in vivo and in vitro. The docking study revealed that secalonic acid D could block the active pocket of topoisomerase І with seven hydrogen bonds between secalonic acid D and ARG488, LYS532, ASP533.
Keywords: Xanthone; antitumor; docking. © 2015 ACG Publications. All rights reserved. |