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Potent Antiplasmodial Alkaloids and Flavonoids from Dasymaschalon acuminatum

Ratchanaporn Chokchaisiri, Waraluck Chaichompoo, Rattana Chalermglin and Apichart Suksamrarn

Department of Chemistry, School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand

Department of Chemistry, Faculty of Science and Technology, and Alternative Medical College, Chandrakasem Rajabhat University, Bangkok 10900, Thailand

Abstract: A new aporphine alkaloid, 7-epi-duguetine (1) together with one known alkaloid, dicentrinone (2), and four known flavonoids, quercetin 3,7-dimethyl ether 3′ -O- α -L-rhamnopyranosyl-(1 g 2)-β-D-glucopyranoside (3), galangin 5-methyl ether (4), 5,7-dimethoxy-3-hydroxyflavone (5), and 3,5,7-trimethoxyflavone (6), were isolated from the leaves of Dasymaschalon acuminatum, a new plant species which has not been investigated phytochemically before. The structures of the isolated compounds were elucidated through extensive NMR spectroscopic analysis. All isolates were evaluated for antiplasmodial activity against Plasmodium falciparum strain K1 and 7- epi -duguetine was found to exhibit potent activity with an IC 50 of 0.385 m g/ml .

Keywords: Dasymaschalon acuminatum; Annonaceae; alkaloid; flavonoid; antiplasmodial activity .© 2015 ACG Publications. All rights reserved.