Identification of Highly Potent and Selective α-Glucosidase Inhibitors with Antiglycation Potential, Isolated from Rhododendron arboreum
Rabia Raza, Zaitoon Ilyas, Sajid Ali, Muhammad Nisar, Muhammad Younas Khokhar and Jamshed Iqbal
Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60000, Pakistan
Institute of Chemical Sciences, University of Peshawar, Peshawar,25120, Pakistan
Abstract: This study explored antidiabetic potential of eight known pure compounds, isolated from the bark of Rhododendron arboreum. Invitro studies of these compounds against α and β-glucosidases revealed them as very potent and selective inhibitors of α-glucosidase. Compound 7 (3-O-acetylursolic acid) was found to be the most potent inhibitor of α-glucosidase with 3.3±0.1µM IC 50 value which was many folds higher than standard inhibitor acarbose. Antiglycation studies of compounds showed that all compounds were also very active antiglycation agents. The studied biological properties of these compounds suggest that they are therapeutically interesting and important tools for treatment of diabetes.
Keywords: Rhododendron arboreum; α-glucosidase inhibitors; antidiabetic; antiglycation. © 2015 ACG Publications. All rights reserved. |