11.

Lignans and Other Constituents from Helianthemum sessiliflorum Pers.

Imane Benabdelaziz, Hamada Haba, Catherine Lavaud, Dominique Harakat and Mohammed Benkhaled

Laboratoire de Chimie et Chimie de lʹEnvironnement (L.C.C.E), Département de Chimie, Faculté des Sciences, Université de Batna, Batna 05000, Algérie

Laboratoire de pharmacognosie, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, BP 1039, 51097 Reims Cedex 2, France

Abstract: One new lignan named 1-O-acetyl prinsepiol (1),in addition to nineteen known compounds including two lignans; 1α-hydroxypinoresinol (2) and (+)˗cycloolivil (3), one fatty acid; ( ̶ )˗pinellic acid (4), f ive phenolic acids; benzoic acid (5), p-hydroxybenzoic acid (6), protocatechuic acid (7), vanillic acid (8) and gallic acid (9), nine flavonoids; ( ̶ )˗epicatechin (10), ( ̶ )˗catechin (11), ( ̶ )˗epigallocatechin (12), ( ̶ )˗gallocatechin (13), astragalin (14), tiliroside (15), quercetrin (16), isoquercetrin (17) and myricitrin (18), and two phytosterols; β-sitosterol (19) and daucosterol (20) were isolated from the aerial parts of AcOEt extract of medicinal plant Helianthemum sessiliflorum Pers . of the family Cistaceae. The structures of all the isolated compounds 1-20 were determined by spectral methods including 1D ( 1H and 13C NMR) and 2D NMR (COSY, HSQC, HMBC and NOESY), HR-ESI-MS, values of optical rotation and chemical correlations with known compounds that have been described in the literature.

Keywords: Helianthemum sessiliflorum ; Cistaceae; lignans; phenolics; NMR. © 2015 ACG Publications. All rights reserved.