23.

Cytotoxic Constituents from bark and leaves of Amyris pinnata Kunth.

Luis Enrique Cuca-Suarez, Franco Della-Monache and Ericsson Coy-Barrera

Laboratorio de Investigación en Productos Naturales Vegetales, Departamento de Química, Universidad Nacional de Colombia, Kr 30 # 45-03, Ciudad Universitaria, Bogotá D.C., Colombia.

Dipartimento di Chimica e Tecnologia del Farmaco, Università di Roma, Roma, Italia.

Laboratorio de Química Bioorgánica, Departamento de Química,Facultad de Ciencias Básicas y Aplicadas, Universidad Militar Nueva Granada, Km 2 vía Cajicá-Zipaquirá, Colombia.

Abstract: From leaves and bark of Amyris pinnata Kunth twelve compounds were isolated, corresponding to six lignans 1-6, three coumarins 7-9, a sesquiterpene 10, an oxazole alkaloid 11, and a prenylated flavonoid 12,. Metabolites were identified by spectroscopic techniques ( 1H and 13C NMR, EIMS) and by comparison with published data in the literature. C ytotoxicity against leukemia, solid tumors, and normal cells was evaluated for all isolated compounds. Lignans were found to be the most cytotoxic compounds occurring in A. pinnata.

Keywords: Amyris pinnata; lignans; coumarins; alkaloid; flavonoid; cytotoxicity . © 2015 ACG Publications. All rights reserved.