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Carboxy Methyl and Carboxy Analogs Argaminolics B and C

Karel D. Klika, Farid Khallouki and Robert W. Owen

Molecular Structure Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

Natural Substances Biochemistry Laboratory, LBSN, FSTE, BP 509, Boutalamine, Errachidia,Morocco

Division of Preventive Oncology, National Center for Tumor Diseases, Im Neuenheimer Feld 460/ German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany

Abstract: Two new analogs, a carboxy methyl (Argaminolic B) and a carboxy derivative (Argaminolic C), of a recently reported amino phenolic, Argaminolic A, isolated from the fruit of the argan tree, Argania spinosa (Skeels L.), are described. Argaminolic B exhibits facile hydrolysis of its methyl ester to yield Argaminolic C, which then undergoes a remarkably facile decarboxylation to the previously described Argaminolic A.

Keywords: Amino phenolics; Argania spinosa (Skeels L.); structural elucidation; spectroscopic analyses . © 2015 ACG Publications. All rights reserved.