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Antioxidant Potential and Inhibition of Key Enzymes Linked to Alzheimer’s Diseases and Diabetes Mellitus by Monoterpene-Rich Essential Oil from Sideritis galatica Bornm. Endemic to Turkey

Gökhan Zengin, Cengiz Sarıkürkçü, Abdurrahman Aktümsek and Ramazan Ceylan

Selcuk University, Science Faculty, Department of Biology, Konya-Türkiye

Suleyman Demirel University, Faculty of Pharmacy, Department of Analytical Chemistry, Isparta-Türkiye

Abstract: The present study was designated to (1) characterize the essential oil from S. galatica (SGEOs) and (2) evaluate its antioxidant and enzyme inhibitory activities. Antioxidant capacity was tested different methods including free radical scavenging (DPPH, ABTS and NO), reducing power (FRAP and CUPRAC), metal chelating and phosphomolybdenum. Inhibitory activities were analyzed on acetylcholiesterase, butrylcholinesterase, α-amylase and α-glucosidase. SGEOs were chemically analyzed and identified by gas chromatography and gas chromatography/mass spectrophotometry. 23 components, representing 98.1% of SGEOs were identified. Monoterpene hydrocarbons (74.1%), especially α- (23.0%) and β-pinene (32.2%), were the main constituents in SGEOs. The main sesquiterpene hydrocarbons were β-caryophyllene (16.9%), germacrene-D (1.2%) and caryophyllene oxide (1.2%), respectively. Generally, SGEOs has shown moderate free radical, reducing power, metal chelating and enzyme inhibitory activities. These activities related to chemical profile in SGEOs. Our findings supported that the possible utility of SGEOs is a source of natural agents for food or pharmaceutical industries.

Keywords: Sideritis galatica ; Antioxidants; Monoterpenes; Cholinesterase; Anti-diabetic. © 2015 ACG Publications. All rights reserved.