16.

Chemical Composition and Cytotoxic Activity of the Essential Oils of Cantinoa stricta (Benth.) Harley & J.F.B. Pastore (Lamiaceae)

Dilamara Riva Scharf, Edésio L. Simionatto, João E. Carvalho, Marcos J. Salvador, Élide P. Santos and Maria Élida A. Stefanello

Department of Chemistry, UFPR, P. O. Box 19081, Curitiba, PR, 81530-990, Brazil

Department of Chemistry, FURB, Blumenau, SC, 89030-080, Brazil

CPQBA, UNICAMP, Campinas, SP, 13081-970, Brazil

Institute of Biology, DBV, PPG BTPB and BV, UNICAMP, Campinas,SP, 13083-970, Brazil

Department of Botanic, UFPR, Curitiba, PR, 81531-990, Brazil

Abstract: The essential oils from the leaves and flowers of Cantinoa stricta (Benth.) Harley & J.F.B. Pastore (Lamiaceae) were obtained by hydrodistillation and analyzed by GC/FID and GC/ MS. The major components of both oils were caryophyllene oxide (leaf – 31.6%; flower – 21.7%) and cis-pinane (leaf – 15.4%; flower – 9.7%). The flower oil also contained significant amounts of a -pinene (9.4%) and b -pinene (9.1%). The oils were tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NCI-H460 (lung), PC-3 (prostate), K-562 (leukemia) human cancer cell lines and against HaCat (no cancer cell), using the sulforhodamine B method. Both oils showed antiproliferative activity against all tested cells lines (TGI < 50 m g/mL), with exception of K562 cells. The highest activity was observed against MCF-7 cell lines (TGI = 4.54-10.36 m g/mL).

Keywords: Lamiaceae; Cantinoa stricta; essential oil; caryophyllene oxide; cytotoxic activity. © 2015 ACG Publications. All rights reserved.