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The Identification of Suberosin from Prangos pabularia Essential Oil and Its Mosquito Activity against Aedes aegypti Nurhayat Tabanca, Maia Tsikolia, Gulmira Ozek, Temel Ozek, Abbas Ali, Ulrich R. Bernier, Ahmet Duran, K. Husnu Can Baser and Ikhlas A. Khan National Center for Natural Products Research, The University of Mississippi, University, MS 38677 USA USDA, ARS, Center for Medical, Agricultural and Veterinary Entomology, Gainesville, FL 32608 USA Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Türkiye Department of Biology Education, Education Faculty, Selcuk University, 42090 Meram- Konya, Türkiye Department of Botany and Microbiology, College of Science, King Saud University, 11451 Riyadh, Saudi Arabia Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677 USA Department of Pharmacognosy, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi Arabia Department of Entomology and Nematology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
Abstract: A detailed analysis of Prangos pabularia Lindl. (Apiaceae) fruit oil was performed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Bicyclogermacrene (21%), (Z)- b -ocimene (19%), a -humulene (8%), a -pinene (8%) and spathulenol (6%) were the main constituents of the oil. One compound with 1.8% at RI 3420 remained unidentified or tentatively identified as suberosin from the Wiley GC-MS Library. T he assumed compound, suberosin was synthesized in two steps and its structure was confirmed by 1D NMR and GC- MS analyses. As part of our continued research to discover new chemicals for use in mosquito control agents as repellents and larvicides, suberosin and its parent compound coumarin were investigated for the mosquito biting deterrent and larvicidal activity against Aedes aegypti. Both suberosin and coumarin showed biting deterrent activity but the activity was lower than the positive control, DEET (N,N-diethyl-3-methylbenzamide). In larval bioassays, suberosin with LC 50 value of 8.1 ppm was significantly more toxic than c oumarin (LC 50 = 49.6 ppm) at 24-h post treatment. These results indicate that suberosin may be useful for use as mosquito larvicidal agent . Keywords:Prangos; suberosin; coumarin ; deterrent activity; larvicidal activity; Aedes aegypti. © 2015 ACG Publications. All rights reserved.
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