New γ -Lactone Carboxylic Acids from the Lichen Parmotrema praesorediosum (Nyl.) Hale, Parmeliaceae

Bui Linh Chi Huynh, Thuc Huy Duong, Thi My Lien Do, Travis George Pinnock, Lawrence Michael Pratt, Shigeki Yamamoto, Hitoshi Watarai, Takao Tanahashi and Kim Phi Phung Nguyen

Dong Nai University, Dong Nai 748355, Vietnam

University of Science, National University – Ho Chi Minh City, Ho Chi Minh City 748355, Vietnam

Sai Gon University, Ho Chi Minh City 748355, Vietnam

Medgarevers College. The University of New York 11225, USA

Osaka University, Osaka 560-0043, Japan

Kobe Pharmaceutical University, Kobe 658–8558, Japan

Abstract: From the lichen Parmotrema praesorediosum (Nyl.) Hale, Parmeliaceae, collected in Vietnam, five new (1, 2, 3, 5, 6) and one known (4) g -lactonic acids were isolated. The structures of the new compounds were established by 1D and 2D NMR spectroscopy, as well as high resolution-electrospray ionization (HR-ESI)-MS analysis. The absolute configuration of new compounds was determined by ultraviolet circular dichroism spectroscopy. Compounds were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 µg/mL. Among six compounds, 1 possessed medium activity against MCF-7 cell line with the inhibition of 52.5%. Meanwhile, the rest showed no cytotoxic activity against three surveyed cancer cell lines.

Keywords:Parmotrema praesorediosum; Parmeliaceae; lichen; aliphatic acids . © 2015 ACG Publications. All rights reserved.