Chemical Constituents of Jacaranda oxyphylla and their Acetylcholinesterase Inhibitory and Antimicrobial Activities

Vinicius Viana Pereira, Roqueline Rodrigues Silva, Lucienir Pains Duarte and Jacqueline Aparecida Takahashi

Chemistry Department , Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, Brazil

Faculty of Pharmacy, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, Brazil

Chemistry Department , Universidade Federal dos Vales do Jequitinhonha e Mucuri, 39100-000, Diamantina, Brazil

Abstract: This study evaluated chemical composition of Jacaranda oxyphylla, acetylcholinesterase inhibitory and antimicrobial activities of the isolated compounds. Phytochemical investigation of leaves extract yielded three classes of substances: fatty compounds, sterols and triterpenes. Butyl hexadecanoate (1), fatty alcohol (2), 2-(4-hydroxyphenyl)ethyl triacontanoate (3), β -sitosterol (4), sitosterol-3-O- β- D -glucoside (5), 6'-palmitoyl-sitosterol-3-O- β- D -glucoside (6), oleanolic acid (7), ursolic acid (8) and corosolic acid (9) were obtained from n-hexane, CHCl 3 and EtOH extracts of J. oxyphylla. It was found a pronounced acetylcholinesterase inhibitory activity for the fatty compounds 1-3 and sterols 5 and 6, with values between 60 to 77%. Substances 7-9 presented a high antibacterial action against Bacillus cereus and Salmonella typhimurium, with values of growth inhibition in the range of 84 to 90%.

Keywords: Bignoniaceae; Jacaranda oxyphylla; acetylcholinesterase inhibition; antibacterial activity. © 2015 ACG Publications. All rights reerved.