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Three Naphthoquinones from Streptomyces sp. XZYN-4 Chunhua Lu, Chen Yang and Zhen Xu Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, P. R. China School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China Abstract : Two new naphthoquinones, named 12-hydroxy-naphthgeranine A (1) and isonaphthgeranine C (2) together with naphthgeranine A (3), were isolated from the cultures of Stereospermum’s rhizosphere strain Streptomyces sp. XZYN-4. Their structure were established on the basis of 1D, 2D-NMR experiments and HR QTOF MS. The absolute configurations of C-12 (12R ) in both (1) and (2) are different from those reported in naphthgeranine family. C ompounds 1 and 3 showed moderate activity against Aspergillus niger ACCC30005 by disk diffusion test at a dose of 20 m g/disk. Keywords:Streptomyces sp. XZYN-4; naphthoquinone; 12-hydroxy-naphthgeranine A, isonaphthgeranine C. © 2016 ACG Publications. All rights reserved.
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