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Chemical Composition, Antioxidant Capacity, Acetyl- and Butyrylcholinesterase Inhibitory Activities of the Essential Oil of Thymus haussknechtii Velen. Handan G. Sevindik, Temel Özek, K. Özden Yerdelen, Mehmet Önal, Hilal Özbek, Zühal Güvenalp and L. Ömür Demirezer Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum, 25240, Türkiye Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir, 26470, Türkiye Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum, 25240, Türkiye Non-wood Products Chief Engineering, Regional Directorate of Forestry, Erzurum, 25050, Türkiye Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara, 06100, Türkiye Abstract: The chemical composition of the essential oil from the aerial parts of Thymus haussknechtii Velen. was analyzed by using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The major component of the essential oil was thymol (52.2%). Total phenolic content of the essential oil was determined as 132.9 µg gallic acid equivalent. The antioxidant capacity was evaluated by DPPH free radical, superoxide anion radical and hydrogen peroxide scavenging activities along with ferrous ion-chelating power test, ABTS radical cation decolorization assay and ferric thiocyanate methods. In addition to antioxidant activity, anticholinesterase activity of the essential oil was also evaluated. It exhibited inhibitory activities on AChE and BuChE which play an important role in Alzheimer’s disease, along with significant antioxidant activity. Keywords: Thymus haussknechtii ; essential oil; antioxidant activity; acetylcholinesterase; butyrylcholinesterase.© 2016 ACG Publications. All rights reserved. |