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Phytochemical and Bioactivity Evaluation of Scrophularia amplexicaulis Benth. Ardalan Pasdaran, Abbas Delazar, Seyed Abdulmajid Ayatollahi, Lutfun Nahar and Satyajit D. Sarker Department of Pharmacognosy, School of Pharmacy, Research and Development Center of Plants and Medicinal Chemistry, Guilan University of Medical Sciences, Rasht, Iran, Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Persons Building, Byrom Street, Liverpool L3 3AF, United Kingdom , Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Persons Building, Byrom Street, Liverpool L3 3AF, United Kingdom Abstract: Scrophularia amplexicaulis Benth. is an Iranian endemic species of the genus Scrophularia, which comprises ca. 200 medicinally important herbaceous flowering plants . Phytochemical investigation of the methanol extract of the aerial parts of this species afforded two iridoid glycosides, scropolioside D (1) and scrophuloside B 4 (2), and two phenylalkanoid glycosides, salidroside (3) and verbascoside (4). S tructures of these compounds were determined by comprehensive spectroscopic analyses. Free-radical-scavenging activity, potential antimalarial property, and contact toxicity as well as general toxicity of the extract and fractions were assessed. Keywords: Scrophularia amplexicaulis ; Scrophulariaceae; iridoid; phenylalkanoid; glycoside; DPPH ( 2,2-diphenyl-1-picrylhydrazyl); antimalarial . © 2016 ACG Publications. All rights reserved.
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