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Biphenyls from the Twigs of Garcinia multiflora and their Anti-Tobacco Mosaic Virus Activities

Xingmeng Xu, Jianlian Shi, Lan Li, Donglai Zhu , Zhenhua Yu, Weny i Yu, Min Zhou, Qiufen Hu, Yadong Guo, Jie Lou, Xuemei Gao and Liang Deng

  School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products, Kunming Medical University, Kunming, Yunnan 650500

Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco yunnan industrial Co., Ltd, Kunming 650231

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R.China

Abstract : For more bioactive compounds, p hytochemical investigations of the acetone extract of the twigs G arcinia multiflora resulted in the isolation of two new bipheny ls, multiflorabiphenyls A and B (1 and 2 ), along with four known biphenyl derivatives (3-6) . Structural elucidations of 1 and 2 were performed by spectral methods such as 1D and 2D NMR spectroscopy, in addition to high resolution mass spectrometry. Compounds 1 and 2 were also evaluated for their anti-tobacco mosaic virus (Anti-TMV) activity. The results showed that compound s 1 and 2 showed high anti-TMV activit ies with inhibition rate s of 25.4 % and 28.3%, respectively, which is close d to that of Ningnanmycin ( 3 3.5 %).

Keywords: Biphenyl; anti-tobacco mosaic virus; G arcinia multiflora . © 2016 ACG Publications. All rights reserved.