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Antimycobacterial and Antifungal Activities of Selected Four Salvia Species

Nur Tan, Dilek Satana, Burcu Sen, Emir Tan, Hilal Bardakcı Altan, Betül Demirci and Meltem Uzun

University of Istanbul, Faculty of Pharmacy, Department of Pharmacognosy, 34116 Beyazit, Istanbul, Türkiye

University of Istanbul, Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 34093 Capa, Istanbul, Türkiye

University of Istanbul Yeni Yuzyil, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 34010 Cevizlibag, Istanbul, Türkiye

Yeditepe University, Faculty of Pharmacy, Department of Pharmacognosy, 34755 Kayisdagi, Istanbul, Türkiye

Anadolu University, Faculty of Pharmacy, Department of Pharmacognosy, 26470 Eskisehir, Türkiye

Abstract: The content of essential oils of endemic Salvia cilicica was analyzed by GC-FID and GC-MS techniques. Spathulenol (23.8 %), caryophyllene oxide (14.9 %) and hexadecanoic acid (10.3 %) were identified as the major components in the oil of Salvia cilicica. Additionally, in this study ethanol extracts of the aerial parts and essential oils of four Salvia species ( S. cilicica, S. officinalis, S. fruticosa, S. tomentosa ) , as well as the roots of S. cilicica were investigated their antimycobacterial and antifungal activities including infectious diseases. The antimycobacterial activity was analyzed against three Mycobacterium tuberculosis (sensitive-, resistant-standard strains and multidrug resistance clinical isolate) strains and the antifungal activity was compared with two dermotophytes (Microsporum gypseum and Trichophyton mentagrophytes var. erinacei) and three Candida species by the broth microdilution method. The essentials oils of the four tested Salvia species showed high antimycobacterial and antifungal activity (MIC between 0.2-12.5 mcg/mL) in comparison to the aerial parts and root extracts . The antifungal and antimycobacterial potential of the ethanol extracts and essential oils were introduced to determine whether, Salvia species can be used in phytotherapy against the yeasts, dermatophytes and M. tuberculosis. To the best of our knowledge this is the first study of S. cilicica about their antimycobacterial and antifungal activities and chemical composition of its essential oils.

Keywords : Salvia species; Salvia cilicica; essential oils; antimycobacterial activity; antifungal activity. © 2016 ACG Publications. All rights reserved.