4.

Guaiane-type Sesquiterpene Lactones from Chrysophthalmum montanum

Perihan Gürbüz, Şengül Dilem Doğan, Leyla Paşayeva and Mehmet Yavuz Paksoy

Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Türkiye,

Department of Pharmaceutical Basic Sciences, Faculty of Pharmacy, Erciyes University, Türkiye,

Department of Environmental Engineering, Faculty of Engineering, Tunceli University, Türkiye.

Abstract: Four new guaiane-type sesquiterpene glycosides (1-4), 4α-hydroxy-guai-1(10)-en-12,8α-olide 2β-O-β-D-glucopyranoside (1), 4α-hydroxy-guai-1(10)-en-12,8α-olide 2β-O-(6΄-trans-caffeoyl)-β-D-glucopyranoside (2), 10α-hydroxy-guai-1(2)-en-12,8α-olide 4α-O-β-D-glucopyranoside (3) and 10α-hydroxy-guai-12,8α-olide 4β-O-β-D-glucopyranoside (4) and three known guaiane-type sesquiterpenes (5-7), 4α,6α-dihydroxy-1β,5α,7αH-guaia-9(10),11(13)-dien-12,8α-olide (5), 6α-acetoxy-4α-hydroxy-1βH-guaia-9(10),11(13)-dien-12,8α-olide (6), and 4β-10α-Dihydroxy-5α-guai-1(2),11(13)-dien-12,8α-olide (7) were isolated from the aerial parts of Chrysophthalmum montanum (DC) Boiss. The structures of the compounds were elucidated by extensive 1D- and 2D-NMR spectroscopic analysis in combination with MS experiments.

Keywords: Chrysophthalmum montanum ; Asteraceae; sesquiterpene lactone glycosides; guaianolides. © 2016 ACG Publications. All rights reserved.