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Antileishmanial Marine Compounds: A Review

Paulo H.B. França, Edeildo F. da Silva-Júnior, Bárbara V.O. Santos, Magna S. Alexandre-Moreira, Lucindo J. Quintans-Júnior, Thiago M. de Aquino and João X. de Araújo-Júnior

Chemistry and Biotechnology Institute, Federal University of Alagoas, CEP 57020-720, Maceió, AL, Brazil

Laboratory of Medicinal Chemistry, School of Nursing and Pharmacy, Federal University of Alagoas, CEP 57020-720, Maceió, AL, Brazil.

Post-Graduate Program in Natural Products and Bioactive Synthetics, Federal University of Paraiba, CEP 58051-900, João Pessoa, PB, Brazil

Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, CEP 57020-720, Maceió, AL, Brazil.

Post-Graduate Program in Health Science, Federal University of Sergipe, CEP 57020-720, Aracaju, Brazil

Abstract: Leishmaniasis is widely ignored in discussion s on the priorities of tropical diseases, and the already-existing drugs present high toxicity or teratogenicity, as well as reduced efficacy due to the emergence of resistant strains. Marine natural products have received increasing attention over the last few decades because of the isolation of metabolites found in many products , with structural pattern not available in terrestrial organisms. Several molecules of marine origin have been investigated in respect of their effects on different species of parasites that cause leishmaniasis . In this study, we review the pharmacological information obtained from the in vitro and in vivo assays on such metabolites.

Keywords: Leishmaniasis; marine compounds; inflammation. © 2016 ACG Publications. All rights reserved.