Records of Natural Products

Year: 2017 Volume: 11   Issue: 2




Phytochemical Characterizationand in vivo Anti-inflammatory and Wound-healing Activities of Argania spinosa (L.) Skeels Seed Oil

Hadjira Dakiche, Mustapha Khali and Houcine Boutoumi

Laboratoire de Protection et de Valorisation des Ressources Agro-Biologiques, Faculté de Sciences de la Nature et de Vie, Université Saâd Dahlab Blida, BP 270, Route de Soumaâ, Blida 09000, Algeria

Centre de Recherche Scientifique et Technique en Analyses Physico-chimiques, BP 384 Zone Industrielle Bou-Ismail RP 42004 Tipaza , Algeria

Abstract: The extracted oil of Argania spinosa (L.) was investigated in regard to its fatty acid composition and polyphenols by Gas Chromatography-Mass Spectrometry (GC–MS) and Ultra-high Performance Liquid Chromatography-Electro Spray Ionization-Quadruple Time Of Flight-Mass Spectrometry (UPLC-ESI-QTOF-MS), respectively. The reduction rate of topical inflammation of extracted oil was calculated using a mouse model. The skin toxicity of argan oil on intact and damaged skin was assessed using a rabbit model. The findings revealed a rich content of monounsaturated and polyunsaturated fatty acids and presence of phenolic acids. The oil exhibited a reduction of inflammation and facilitated a healing process without any irritation. The experimental study revealed that A. spinosa seed oil displays remarkable wound-healing and anti-inflammatory activities related to its chemical composition. Argan oil has positive potential for skin medicinal application.

Keywords: Argania spinosa (L.) Skeels; oil; chemical composition; anti-inflammatory; wound-healing. © 2016 ACG Publications. All rights reserved.