15.

Antidiabetic Flavonol Glycosides from Eryngium caeruleum

Attiq Ur Rehman, Muhammad Ali Hashmi, Yildiz Tehseen , Afsar Khan, Saleha Suleman Khan, Jamshed Iqbal, Shagufta Perveen, Sehroon Khan, Umar Farooq and Viqar Uddin Ahmad

Department of Chemistry and 2 Center for Advance Drug Research, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia

Abstract: Phytochemical investigation of the aerial parts of Eryngium caeruleum led to the isolation of two new source flavone glycosides (1 and 2). The structures of these compounds were determined with the help of one- and two-dimensional (1D- and 2D-) NMR techniques including 1H-NMR, 13C-NMR, HMQC, HMBC, 1H- 1H COSY, and NOESY experiments. The compounds were studied for their in vitro aldose reductase (ALR1 and ALR2) and glucosidase (α and β) inhibitory activities, and antiglycation potential. Both the compounds showed higher inhibition potential against ALR1 than ALR2. Compound 2 showed three fold higher potency against ALR2 than the reference drug Sorbinil. In silico studies were performed to understand the binding mechanism of these compounds to aldose reductase .

Keywords: Eryngium caeruleum ; flavone glycosides; aldose reductase; glucosidase; antiglycation; molecular docking. © 2016 ACG Publications. All rights reserved.