Ionol D erivative s from Euphorbia tirucalli Wen Xu, Jing Yang, Xi Zhu, Yikao Hu, Shaohua Xu, Yuanyuan Li and Yong Zhao College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China West China School of Pharmacy, Sichuan University, Chengdu 6 10041 , China
Abstract: A new ionol derivative, ( 2R, 6 S , 9 S ) -2-hydroxy -3-oxo-α-ionol (1), together with three known analogues, (6 S ,9 S )- 6-hydroxy- 3-oxo-α-ionol (2) , (6 R ,9 S )-3-oxo-α-ionol β -D- g lucopyranoside (3) and (6 R ,9 R )-3-oxo-α-ionol β -D-glucopyranoside (4), were isolated from the ethyl acetate extract of the aerial parts of Euphorbia tirucalli . Their structures were elucidated by means of extensive spectroscopic methods and comparison with the data reported in the literature. The absolute configuration of 1 was deduced by comparing experimental and calculated ECD spectra and 13C NMR data. The ionol d erivative s have been obtained for the first time from the genus Euphorbia.
Keywords: Euphorbia tirucalli ; ionol d erivative s ; structure elucidation. © 2017 ACG Publications. All rights reserved.
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