Records of Natural Products

Year: 2018 Volume: xx   Issue: x

 

  SHORT REPORT

5.

Antileishmanial Activity of a New ent-Kaurene Diterpene Glucoside Isolated from Leaves of Xylopia excellens R.E.Fr. (Annonaceae)

Danielle C. Alencar, Felipe M. A. da Silva, Richardson A. de Almeida, Emmanoel V. Costa, Lívia M. Dutra, Andersson Barison, Helito Volpato, Celso V. Nakamura, Hector H. F. Koolen, Afonso Duarte L. de Souza and Maria Lúcia B. Pinheiro

 Departamento de Química, Universidade Federal do Amazonas, 69077-000, Manaus, AM, Brasil

Centro de RMN, Universidade Federal do Paraná, 81531-990, Curitiba, PR, Brasil

Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Universidade Estadual de Maringá, 87020-900, Maringá, PR, Brasil

Grupo DeMpSter de Espectrometria de Massas, Universidade do Estado do Amazonas, 69050-010, Manaus, AM, Brasil

Abstract: This work describes a new ent-kaurene diterpene glucoside, 7β-O-β-D-glucopyranoside-ent-kaur-16-ene, from the leaves of Xylopia excellens R.E.Fr. (Annonaceae). The compound showed high in vitro antileishmanial activity (IC 50 of 15.23 ± 0.64 µg/mL) towards promastigote forms of Leishmania amazonensis, and low cytotoxicity against J774A1 cells (SI of 1.96).

Keywords: Annonaceae;ent-kaurene diterpene; Leishmania amazonensis; Xylopia excellens. © 2017 ACG Publications. All rights reserved.