1.

A New Dibenzofuran from the Barks of Sorbus commixta

 Seong Yeon Choi, Birang Jeong, Hyeon Seok Jang, Jiho Lee, Kiwon Ko, Hyunha Kim, Jua Hong, Young Soo Bae and Heejung Yang

College of Pharmacy; Kangwon National University, Chuncheon 24341, Republic of Korea

College of Forest and Environmental Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea

Abstract:A new dibenzofuran derivative, 1,2,4-trimethoxydibenzofuran-3,9-diol (7), was isolated from the ethyl acetate fraction of Sorbus commixta barks, along with six known compounds, lupeol (1), betulin (2), betulinic acid (3), ursolic acid (4), b -sitosterol (5) and b -pyrufuran (6). Their structures were determined by NMR spectroscopic analysis, including of 1H and 13C NMR, 1H- 1H COSY, HSQC and HMBC spectra data. Cytotoxic activities of seven compounds were evaluated in five cancer cell lines, HEp-2, A549, MCF-7, PC-3 and SKOV-3 at the concentrations ranging from 10 to 100 m M.

Keywords: Sorbus commixta; triterpenes; dibenzofuran; 1,2,4-trimethoxydibenzofuran-3,9-diol , cytotoxicity. © 2017 ACG Publications. All rights reserved.