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New Cytotoxic Pregnane-type Steroid from the Stem Bark of Aglaia elliptica (Meliaceae)

 Kindi Farabi, Desi Harneti, Nurlelasari, Rani Maharani, Ace Tatang Hidayat, Khalijah Awang, Unang Supratma and Yoshihito Shiono  

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia

Central Laboratory of Universitas Padjadjaran, Jatinangor 45363, Sumdeang, Indonesia

Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia

Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan

Abstract:A new pregnane-type steroid, 2α-hydroxy-3α-methoxy-5α-pregnane (1), together with three known dammarane-type triterpenoid, 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (2), 20S,24S-epoxy-3α,25-dihydroxydammarane (3), and eichlerianic acid (4) have been isolated from the stem bark of Aglaia elliptica. The structure s were determined by spectroscopic methods including the 2D-NMR techniques. Compound 1-4 showed moderate cytotoxic activity against P-388 murine leukemia cells .

Keywords: Pregnane-type steroid; Aglaia elliptica; cytotoxic activity; Meliaceae . © 2017 ACG Publications. All rights reserved.