Anti-cholinesterase Activities of Hydrolysable Tannins and Polyhydroxytriterpenoid Derivatives from Terminalia chebula Retz. Fruit Min-Soo Kim, Dong Young Lee, Sang Hyun Sung and Won Kyung Jeon
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, South Korea College of Pharmacy, Seoul National University, Seoul 08826, South Korea Abstract: In the present study, 48 hydrolysable tannins and 12 polyhydroxytriterpenoid derivatives were isolated from Terminalia chebula fruit and assessed for their inhibitory activities on cholinesterases in vitro. Among them, phyllanemblinin F (compound 35), chebulanin (36), 23-Galloyl arjunolic acid (55), and Arjunetin (=24-deoxy sericoside) (56) showed strong inhibition against acetylcholinesterase (AChE) with IC 50 values of 24.02, 21.36, 67.25, and 47.85 μM, respectively. Though corilagin (15) and several gallotannins (8, 12, 14) exhibited weak inhibitory activity against butyrylcholinesterase, the majority of compounds from T. chebula showed inhibition of AChE. Since cognitive dysfunction is closely related to diminution of cholinergic transmission, our results suggest that compounds from T. chebula could be used as potential treatment for dementia. Keywords: Terminalia chebula ; anti-cholinesterase; dementia. © 2018 ACG Publications. All rights reserved. |