JOURNAL


Bioorganic & Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2018 Issue: 1 January-December
PAGES
p.2 - 5
STATISTICS
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AUTHORS
  • Furkan Ayaz
  • 1 - Mersin University Faculty of Arts and Science, Department of Biotechnology, Türkiye
PDF OF ARTICLE

ABSTRACT


Osteogenesis is the process of bone formation and it is regulated mainly by two types of cells, osteoblasts and osteoclasts. There is a fine balance in the function of these cells in order to reach the proper bone mass in the tissue. This balance is regulated by signaling molecules in the macroenvironment. There have been a growing body of evidence that macrophages contribute significantly to this process by producing signaling molecules or in some cases by directly interacting with the tissue resident cells. In this review, the concept of immunomodulation to enable bone formation in the damaged bone tissues, is discussed with support of the recent studies in the field.  

KEYWORDS
  • Macrophages
  • immunomodulation
  • bone
  • bone formation
  • osteoporosis
  • immunomodulatory agents