JOURNAL 1666


Bioorganic & Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2020 Issue: 1 January-June
PAGES
p.15 - 21
STATISTICS
Viewed 64 times.
AUTHORS
  • Burak Kuzu
  • Ceylan Hepokur
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The present study was carried out in the attempt to design a new class of potential anticancer agents comprising sixteen compounds (10-25) sharing the alicyclic diamide as a core. Their biological potential towards breast cancer was tested by using MTT assay on breast cancer (MCF-7)and non-tumorigenic breast (MCF-10-2A)cell lines. Screening results show that the anti-proliferative effects of compounds (13, 19 and 20) correlate with the lipophilicity and selectivity of compounds. Interestingly, the active compounds distinguished from others with a quite high selectivity value that is comparable to 5-FU. Therefore, new small molecules containing alicyclic diamide fragments will have a significant contribution to the development of new era anticancer drug candidates for breast cancer.

KEYWORDS
  • Phenyl alicyclic diamides
  • breast cancer
  • anti-proliferative
  • anti-cancer