JOURNAL 1532


Journal of Chemical Metrology
VOLUME & ISSUE
Available Online: April 19,2020
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/jcm.36.20.01.1532
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Demet Dincel
  • Hatice Olgan
  • Zeynep Canbaloglu
  • Sule Yalcin
  • Aysen Erkucuk
  • Gizem Tiris
  • Ahmet C. Gören
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Adulteration of dietary supplements are serious threats to public health in all around of world. Nowadays, in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial or harmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicin in dietary supplements via Fortis C18 (150 x 3 mm; 3 µm) column at 25 °C was developed and validated in a mixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formic acid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min.  The recoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 for dihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplements products for adulteration to increase the effects of product without any declaration.  

KEYWORDS
  • Capsaicin
  • dihydrocapsaicin
  • LC-MS/MS
  • adulteration
  • lose weight
  • dietary supplements

SUPPORTING INFORMATION


Supporting Information
Download File 36-JCM-2001-1532-SI.pdf (382.39 KB)