JOURNAL 545


Records of Natural Products
VOLUME & ISSUE
Year: 2015 Issue: 3 July-September
PAGES
p.312 - 322
STATISTICS
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AUTHORS
    Sara Boussaha, Khadidja Bekhouche, Azzedine Boudjerda, Francisco Leόn, Serkan Koldaş, Ayse Sahin Yaglioglu, İbrahim Demirtaş, Ignacio Brouard, Eric Marchioni, Djamila Zama, Samir Benayache and Fadila Benayache
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Phytochemical investigations of extracts from the aerial parts (leaves and flowers) of Perralderia coronopifolia Cosson resulted in the isolation of nine secondary metabolites corresponding to three flavonoids: rhamnazin(1), chrysosplenol D (3), and (2R, 3R) taxifolin (4), two monoterpene glycosides : myrtenol- β-D-glucopyranoside- 6'-O-acetate (2) and myrtenol β-D-glucopyranoside (7), a disaccharide: sucrose (9) and three di-O-caffeoylquinic acid derivatives : methyl 3, 5-di-O-caffeoyl quinate (5 ) and methyl 3,4-di-O-caffeoyl quinate (6 ) as a mixture and 1,5-di-O-caffeoylquinic acid (8). The structures were identified by spectroscopic methods such as 1H and 13C NMR, COSY, HSQC and HMBC experiments, HRESI-MS and comparison with literature data. Myrtenol-β-D-glucopyranoside-6'-O-acetate (2) was isolated in pure and native state for the first time. The other compounds are new for the genus Perralderia Cosson. The ethyl acetate extract showed a high antioxidant effect, especially DPPH radical scavenging activity with IC 50=7.01±0.28µg/mL) compared to ascorbic acid ( IC 50= 5±0.1µg/mL . This extract also showed antiproliferative activity against HeLa (human cervix carcinoma) and C6 (rat brain tumor) cells.

KEYWORDS
  • Asteraceae
  • Perralderia coronopifolia
  • flavonoids
  • caffeoylquinic acids
  • terpenoids
  • antioxidant activity