JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: April 02,2019
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.121.18.11.1033
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Kui-Wu Wang
  • Xiaoxin Wang
  • Haijiang Zhang
  • Yichao Ge
  • 1 - School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P.R. China
  • 2 - School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P.R. China
  • 3 - Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huaian 223003, P. R. China
  • 4 - Ocean College, Zhejiang University, Hangzhou 310058, P. R. China
PDF OF ARTICLE

ABSTRACT


Chemical investigation of the aerial part of Illigera aromatic S.Z. Huang & S.L. Mo has resulted in the isolation and characterization of one new aporphine alkaloid, illigerine B (1), along with three known analogues laurodionine B (2), N-formyl-laurolitsine (3) and illigerine A (4). Their structures were established by spectrometric means and physico-chemical properties. The in vitro cytotoxic activities of compound 1 against Hela, SMMC7721, and Bcap37 cell lines were evaluated. Compound 1 exhibited moderate cytotoxic activity against the three tumor cell types, with IC50 values of 12.40 ± 0.78, 32.61 ± 2.05, and 28.69 ± 1.80 μg/mL. This work shown that aporphine alkaloids might be useful as characteristic markers in chemotaxonomic research of the genus Illigera.

KEYWORDS
  • Hernandiaceae
  • Illigera aromatic
  • Aporphine alkaloid
  • lligerine B
  • Cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File 121-RNP-1811-1033-SI.pdf (2.03 MB)