JOURNAL 1757


Records of Natural Products
VOLUME & ISSUE
Available Online: October 20,2020
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.207.20.07.1757
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Hsu-ming Chung
  • Ling-tsung Hsiao
  • Zong-you Li
  • Zhi-hong Wen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A chemical investigation was carried out on a crinoid Colobometra perspinosa collected from Hengchun Peninsula in the South China Sea, which led to the isolation of five angular naphthopyrones (15), including one new metabolite, 8-hydroxy-5,6,10-trimethoxy-2-pentyl-4H-naphtho[1,2-b]pyran-4-one (1). Their structures were assigned based on spectroscopic methods, including UV, HRESIMS, 1D- and 2D-NMR spectra. The anti-inflammatory activity of the isolated compounds was evaluated and compound 5 was found to inhibit the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophages.

KEYWORDS
  • angular naphthopyrone
  • crinoid
  • Colobometra perspinosa
  • iNOS

SUPPORTING INFORMATION


Supporting Information
Download File 207-RNP-2007-1757-SI.pdf (1.46 MB)