JOURNAL 1302


Records of Natural Products
VOLUME & ISSUE
Available Online: September 11,2019
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.147.19.06.1302
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Latifah Al Shammari
  • Abdullah Al Mamun
  • Darja Koutova
  • Martina Majorosova
  • Daniela Hulcova
  • Marcela Safratova
  • Katerina Breiterova
  • Jana Marikova
  • Radim Havelek
  • Lucie Cahlíková
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Different species, hybrids and varieties of the genus Hippeastrum (Amaryllidaceae) are planted for ornamental purposes and at the same time they represent a rich source of interesting secondary metabolites called Amaryllidaceae alkaloids. These compounds display a wide spectrum of biological activities. In the current study, six Hippeastrum taxa were evaluated for their alkaloid profile by GC-MS. Using preparative TLC, five alkaloids were isolated in pure form, and three of them evaluated for cytotoxic and antiproliferative potencies on a panel of human cancer cells of different histotype (Jurkat, MOLT-4, A549, HT-29, PANC-1, A2780, HeLa, MCF-7 and SAOS-2). In parallel, normal MRC-5 human fibroblasts were employed to determine the compounds´ overall toxicity against non-cancer cells. The most intriguing cytotoxic profile was demonstrated by montanine (1) with IC50 values between 1.04 – 1.99 µM.

KEYWORDS
  • Amaryllidaceae
  • Hippeastrum
  • alkaloids
  • montanine
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File 148-RNP-1906-1302-SI.pdf (1.73 MB)