JOURNAL 1448


Records of Natural Products
VOLUME & ISSUE
Available Online: January 13,2020
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.165.19.10.1448
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Valeria Romanucci
  • Maria Giordano
  • Sergio Davinelli
  • Cinzia Di Marino
  • Afef Ladhari
  • Anna De Marco
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Gymnema sylvestre is a commonly used herb in Ayurvedic medicine. The demand for its extracts in the commercial and pharmaceutical fields has been steadily increasing in recent years. Its extracts are used to treat various ailments as well as for their antimicrobial properties. This study has evaluated the antimicrobial effects of different G. sylvestre extracts and of eight triterpenes isolated from the most active extract on six bacterial poultry pathogens i.e. Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterobacter aerogenes. In particular, it has been evaluated the minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of all extracts and isolated triterpenes. Finally, the cytotoxicity activity of triterpenes was evaluated by MTT assay and their antioxidant activity in basal and oxidant conditions by DCFH-DA assay.

KEYWORDS
  • Gymnema sylvestre
  • antimicrobial effects
  • triterpenes
  • gymnemic acids
  • herbal drug
  • DCFH-DA assay

SUPPORTING INFORMATION


Supporting Information
Download File 165-RNP-1910-1448-SI.pdf (1.97 MB)