JOURNAL 1774


Records of Natural Products
VOLUME & ISSUE
Available Online: October 28,2020
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.204.20.08.1774
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 138 times.
AUTHORS
  • Jian Zhou
  • Jinhua Wen
  • Jianhua Huang
  • Pengfei Chen
  • Xiao-Chi Ma
  • Rongjing Sun
  • Chao Wang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The phytochemical investigation has been performed for Euphorbia ebracteolata, the roots of which are usually used natural medicine in traditional Chinese medicine for the treatments of tuberculosis and bacterial infection. A diterpenoid has been obtained using silica gel and ODS column chromatography. Furthermore, on the basis of widely spectroscopic data analyses, including 1D-, 2D-NMR, HR-ESIMS and ECD, the isolated compound was determined to be a rosane type diterpenoid, which possessed a rare aromatic ring. The isolated diterpenoid as a new compound was named ebraphenol E (1). The bioactivity of isolated diterpenoid (1) has been evaluated and moderate inhibitory effect on lipase (IC50 = 12.5 μM) was observed. In combination with our previous phytochemical investigations about E. ebracteolata, the chemotaxonomic significance of diterpenoids was summarized for E. ebracteolata.

KEYWORDS
  • Euphorbia ebracteolata
  • rosane diterpenoid
  • ebraphenol E
  • lipase
  • Chemotaxonomy

SUPPORTING INFORMATION


Supporting Information
Download File 204-RNP-2008-1774-SI.pdf (1.63 MB)