JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: November 15,2018
PAGES
p.1 - 13
DOI ADDRESS
http://doi.org/10.25135/rnp.109.18.09.875
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 105 times.
Downloaded 1 times
AUTHORS
  • Gulmira Özek
  • M. Ufuk Özbek
  • Süleyman Yur
  • Fatih Göger
  • Munevver Arslan
  • Temel Özek
  • 1 -
  • 2 - Department of Biology, Faculty of Science, Gazi University, 06500, Teknikokullar, Ankara, Turkey
  • 3 - Medicinal Plant, Drug and Scientific Research Center (AUBIBAM), Anadolu University, 26470 Eskisehir,
  • 4 - Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470, Eskisehir, Turkey
  • 5 - Research Institute for Forest Soil and Ecology, p.b. 61, 26160, Eskişehir, Turkey
  • 6 - Anadolu University, Faculty of Pharmacy, Pharmacognosıs Department,Yeşiltepe 26210, Tepebaşı,Eskişehir, Türkiye
PDF OF ARTICLE

ABSTRACT


In the present work, chemical compositions of essential oil and methanol extract of endemic Cota fulvida (Grierson) Holub investigated as well as their antioxidant, antidiabetic, antiinflammatory and antimelanogenesis potent. The phytochemical analyses have been performed with GC-MS/FID and LC-MS/MS techniques. The essential oil was characterized with hexadecanoic acid (25.6 %), camphor (6.1 %), caryophyllene oxide (5.3 %), 1,8-cineole (4.9 %) and humulene epoxide (3.9 %). In the extract, phenolic acids, phenylpropanoid dimer and flavonoids were detected. The major constituents of the extracts were found to be 5-feruloylquinic acid, caftaric acid, 3,5-O-dicafeoylquinic acid and quercetin rutinoside. The antioxidant activities of the oil and extract were evaluated through scavenging of free radicals, inhibition of linoleic acid peroxidation and superoxide anion radical (O2-) generated by xanthine - xanthine oxidase (XO) system. The extract showed free radical scavenging activity (IC50 0.131 mg/mL), Trolox equivalent antioxidant capacity (1.33 mM) and inhibited (Inh. 36.3 %) peroxidation of lipids. The oil and extract demonstrated significant hypoglycemic activity via inhibition of porcine pancreatic a-amylase. The antiinflammatory effects of the oil and extract via inhibition of 5-LOX enzyme were found as 53.7 % and 23.9 %, respectively. The extract demonstrated moderate inhibitory effect (23.3 %) on oxidation of L-DOPA via inhibition of tyrosinase enzyme.

KEYWORDS
  • Cota fulvida
  • Essential Oil
  • Extract
  • GC-MS/FID
  • LC-MS/MS
  • Antioxidant

SUPPORTING INFORMATION


Download File 109-RNP-1809-875-SI.pdf (718.27 KB)