JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: June 16,2019
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.135.18.11.1074
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Fatma Ayaz
  • Esra Küpeli Akkol
  • Nezhun Gören
  • İhsan Çalış
  • F. Tuğçe Gürağaç Dereli
  • Hayri Duman
  • Muhammad Iqbal Choudhary
  • Nurgün Küçükboyacı
  • 1 - Selçuk University
  • 2 - Gazi University
  • 3 - Yildiz Technical University, Department of Molecular Biology and Genetics Department, 34349 Beşiktaş-İstanbul, Türkiye
  • 4 - N.T.R. Cyprus, Near East Boulevard, ZIP: 99138 Nicosia/TRNC Mersin 10, Türkiye
  • 5 - Gazi University
  • 6 - Gazi University
  • 7 - University of Karachi
  • 8 - Gazi University
PDF OF ARTICLE

ABSTRACT


The aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) is traditionally used for wound healing, as well as for the treatment of common cold, sinusitis, and other inflammatory diseases. The objectives of this study were to identify potential anti-inflammatory effects of the methanol extract, and its different polarity subextracts (n-hexane, chloroform, n-butanol, and remaining aqueous), and guaianolide-type sesquiterpene lactones [6α-acetoxy-4α-hydroxy-1βH-guaia-9.11(13)-dien-12.8α-olide (1), 6α-acetoxy-4α-hydroxy-9β.10β-epoxy-1βH-guaia-11(13)-en-12.8α-olide (2), 4α,6α-dihydroxy-1β,5α,7αH-guaia-9(10),11(13)-dien-12,8α-olide (3), and (4α,5α,8β,10β)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide (4)] from the aerial parts of C. montanum. In order to evaluate the anti-inflammatory activity of C. montanum, carrageenan- and PGE2-induced hind paw edema, and acetic acid-induced increase in capillary permeability mice models were used. The methanol extract, the chloroform subextract, and compounds 3, and 4 were shown to possess anti-inflammatory activity in in vivo models at 100 mg/kg dose. The results provide a biological, and phytochemical basis for the traditional use of C. montanum aerial parts for inflammatory conditions in Turkish folk medicine.

KEYWORDS
  • Asteraceae
  • Chrysophthalmum montanum
  • sesquiterpene lactones
  • anti-inflammatory
  • carrageenan
  • prostaglandins