JOURNAL 1728


Records of Natural Products
VOLUME & ISSUE
Available Online: October 17,2020
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.199.20.07.1728
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 13 times.
AUTHORS
  • Ronglu Yu
  • Mingzhu Li
  • Yi Wang
  • Xuelian Bai
  • Jianwei Chen
  • Xingnuo Li
  • Hong Wang
  • Huawei Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Chemical investigation of a co-culture of two endophytic fungi Aspergillus fumigatus D and Fusarium oxysporum R1 from two traditional medicinal plants, Edgeworthia chrysantha Lindl. and Rumex madaio Makino, led to isolation of a new amide 1 and six known compounds, including neovasinin (2), neovasifuranone B (3), N-(2-phenylethyl)acetamide (4), α-linolenic acid (5), α-elaeostearic acid (6), palmitoleic acid (7). On the basis of extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS and optical rotation measurement as well as comparison of literature data, chemical structure of 1 was unambiguous elucidated as (S, E)-methyl-2-(2,4-dimethylhex-2-enamido)acetate. Bioassay results indicated that none of these compounds exhibited strong inhibitory effect on three human pathogens Escherichia coli, Staphyloccocus aureus and Candida albicans with MIC values of ≥25 μM.

KEYWORDS
  • Endophytic fungus
  • Aspergillus fumigatus D
  • Fusarium oxysporum R1
  • co-culture
  • amide
  • antimicrobial effect

SUPPORTING INFORMATION


Supporting Information
Download File 199-RNP-2007-1728- SI.pdf (1.35 MB)