JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: August 04,2018
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.89.18.05.296
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 41 times.
Downloaded 27 times
AUTHORS
    Jiao Zhang, Yuze Li, Yuwen Cui, Pu Jia, Zhenggang Yue, Bei Song and Xiaomei Song
PDF OF ARTICLE

ABSTRACT


A new C 18-diterpenoid alkaloid, along with four known diterpenoid alkaloids have been isolated from the roots of Aconitum sinomontanum. Their structures were established as sinomontanine I (1), delcosine (2), lepenine (3), napelline (4), and kirinine B (5) by extensive spectroscopic techniques and chemical methods. The immunosuppressive effects of compounds 1 –4 were evaluated in vitro through ConA-induced or LPS-induced splenocyte proliferation, with IC 50 values of 8.909 μM, 1.515 μM , 5.078 μM, and 1.167 μM ( ConA-induced ) , or 3.661 μM, 4.417 μM, 5.129 μM, and 1.830 μM (LPS-induced), and compounds 1 –4 showed a significant cytotoxic effect with CC 50 values of 447.5 μM, 702.2 μM, 310.6 μM and 794.1 μM, respectively. The CC 50/IC 50 value of 2 and 3 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis.

KEYWORDS
  • Aconitum sinomontanum Nakai
  • diterpenoid alkaloids
  • immunotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File 89-RNP-1805-296-SI.pdf (1.55 MB)