JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: August 04,2018
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.89.18.05.296
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
    Jiao Zhang, Yuze Li, Yuwen Cui, Pu Jia, Zhenggang Yue, Bei Song and Xiaomei Song
PDF OF ARTICLE

ABSTRACT


A new C 18-diterpenoid alkaloid, along with four known diterpenoid alkaloids have been isolated from the roots of Aconitum sinomontanum. Their structures were established as sinomontanine I (1), delcosine (2), lepenine (3), napelline (4), and kirinine B (5) by extensive spectroscopic techniques and chemical methods. The immunosuppressive effects of compounds 1 –4 were evaluated in vitro through ConA-induced or LPS-induced splenocyte proliferation, with IC 50 values of 8.909 μM, 1.515 μM , 5.078 μM, and 1.167 μM ( ConA-induced ) , or 3.661 μM, 4.417 μM, 5.129 μM, and 1.830 μM (LPS-induced), and compounds 1 –4 showed a significant cytotoxic effect with CC 50 values of 447.5 μM, 702.2 μM, 310.6 μM and 794.1 μM, respectively. The CC 50/IC 50 value of 2 and 3 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis.

KEYWORDS
  • Aconitum sinomontanum Nakai
  • diterpenoid alkaloids
  • immunotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File 89-RNP-1805-296-SI.pdf (1.55 MB)