JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: June 05,2019
PAGES
p.1 - 8
DOI ADDRESS
http://doi.org/10.25135/rnp.19.03.1224
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Abdulsalam A.M. Alkhaldi
  • Arafa Musa
  • Ehab M. Mostafa
  • Elham Amin
  • Harry P. De Koning
  • 1 - Department of Biology, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia
  • 2 - Department of Pharmacognosy, College of Pharmacy, Jouf University, 2014, Sakaka, Saudi Arabia
  • 3 - Department of Pharmacognosy, College of Pharmacy, Jouf University, 2014, Sakaka, Saudi Arabia
  • 4 - Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 62514, Egypt
  • 5 - Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
PDF OF ARTICLE

ABSTRACT


Phytochemical study of the ethanolic extract of Scrophularia syriaca Benth. was attained by chromatographic and spectroscopic procedures, which resulted in isolation of eight compounds; 6-O-α-L- rhamnopyranosylcatalpol (1), scropolioside B (2), gmelinoside-L (3), 8-acetyl harpagide (4), scropolioside D (5), scropolioside D2 (6), quercetin (7) and kaempferol-3-O-rutinoside (8). The antiprotozoal activity was evaluated against Trypanosoma brucei brucei (s427-WT), Trypanosoma brucei brucei (TbAT1-B48), Leishmania major and Leishmania mexicana. Compounds 2, 5, 7 and 8 exhibited mild to moderate activities against kinetoplastid parasites compared to pentamidine positive control, the mechanism of antiprotozoal activity was predicted by the molecular docking studies on the target enzyme Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH).

KEYWORDS
  • docking
  • iridoids
  • Leishmania
  • Trypanosoma
  • Scrophularia syriaca

SUPPORTING INFORMATION


Scrophularia Syriaca photo

a photo of Scrophularia Syriaca plant growing in northern Saudi Arabia in the flowering stage

Supporting Information
Download File 129-RNP-1903-1224-SI.pdf (389.5 KB)