JOURNAL 1856


Records of Natural Products
VOLUME & ISSUE
Available Online: January 01,2021
PAGES
p.1 - 4
DOI ADDRESS
http://doi.org/10.25135/rnp.218.20.10.1856
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Ying Lu
  • Yifang Chen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new eudesmane sesquiterpene (1), named sapleudesone, together with four known analogs (25) were isolated from the aerial parts of Salvia plebeia. The structure of compound 1 was established by NMR and HRESIMS data, and the absolute configuration of 1 was determined by comparing the experimental ECD spectrum with the calculated ECD spectra. The known compounds were identified to be salplebeone A (2), linderolide I (3), chlorantene D (4), and chlomultin B (5) by comparing the NMR data and specific rotations with reported data. All five compounds were tested for the inhibitory effects against NO production in LPS-activated RAW 264.7 macrophages, As a result, compound 2 exhibited weak inhibitory effects with an IC50 value of 42.3  1.4 uM.

KEYWORDS
  • eudesmane sesquiterpene
  • Salvia plebeia;
  • NO production
  • inhibitory effects

SUPPORTING INFORMATION


Supporting Information
Download File 218-RNP-2010-1856-SI.pdf (792.49 KB)