JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: June 22,2019
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.139.19.04.1263
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Ebru Erol
  • Zulfiqar Ali
  • Mehmet Ozturk
  • Shabana Khan
  • Ikhlas Khan
  • 1 - Department of Chemistry, Mugla Sıtkı Kocman University, Kötekli 48121, Mugla, Turkey
  • 2 - 2National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, U
  • 3 - Mugla Sitki Kocman University, Faculty of Science, Department of Chemistry, Mugla 48121, Turkey
  • 4 - University of Mississippi School of Pharmacy
  • 5 - National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Un
PDF OF ARTICLE

ABSTRACT


Abstract

Tricholoma caligatum (Viv.) Ricken is an edible mushroom that belongs to matsutake group. The first chemical investigation of the three different extracts of Tricholoma caligatum resulted in two new compounds, 8-demethoxylascivol (1) and 8-epi-lascivol (2) and six known compounds, lascivol (3), trametenolic acid (4), ergosterol (5), ergosterol peroxide (6), 5a, 6a-epoxyergosterol (7), and cerebroside B (8). Their structures were elucidated by spectroscopic analyses including 1D and 2D NMR data. The biological activities of all the compounds were evaluated toward multiple targets related to inflammation and metabolic disorder such as NF-κΒ, iNOS and ROS. The findings of this study reveal that the edible mushroom Tricholoma caligatum could be a potential source for anti-inflammatory bioactive metabolites.

KEYWORDS
  • Tricholoma caligatum
  • iNOS
  • NF-κΒ
  • anti-inflammatory
  • lascivol

SUPPORTING INFORMATION


Supporting Information
Download File 139-RNP-1904-1263-SI.pdf (3.31 MB)