JOURNAL 1702


Records of Natural Products
VOLUME & ISSUE
Available Online: September 26,2020
PAGES
p.1 - 8
DOI ADDRESS
http://doi.org/10.25135/rnp.201.20.07.1702
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Ekrem Köksal
  • Yakup Ulutaş
  • Samed Şimşek
  • Taha Bayraktar
  • Ahmet Altay
  • Mustafa Çatır
  • İbrahim Demirtaş
  • Ali Rıza Tüfekçi
  • Ali Kandemir
  • Cemalettin Alp
  • Mohammed B. Anwer Alemdar
  • Hüseyin Akşit
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Secondary metabolites of Tanacetum alyssifolium (Bornm.) Grierson (Asteraceae) were investigated for the first time. Thirteen compounds including axillarin (1), Luteolin-7-O-β-glucoside (8) and rutin (13) as flavonoids, fraxetin (7), isofraxidin (9), isofraxidin-7-O-glucoside (11) and fraxidin (12) as coumarins, tatridin A (2), altissin (3), tamirin (4) and tanachin (5) as sesquiterpene lactones and 2,4-dihydroxy-6-methoxy acetophenone (6) and picein (10) as acetophenone derivatives were isolated from the methanol extract of the species. The structures of all isolated compounds were elucidated by 1D and 2D-NMR techniques and by comparing with the literature data. In addition, in vitro cytotoxic activity of all isolated compounds was evaluated against breast cancer MCF-7 cell line by XTT assay. Sesquiterpene lactones; tatridin A (2), tamirin (4) and tanachin (5) were found to be the most cytotoxic molecules against MCF-7 cell line.

KEYWORDS
  • Tanacetum alyssifolium
  • sesquiterpene lactones
  • cytotoxicity
  • MCF-7 cell line

SUPPORTING INFORMATION


Supporting Information
Download File 201-RNP-2007-1702-SI.pdf (2.28 MB)