JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: August 27,2018
PAGES
p.1 - 7
DOI ADDRESS
http://doi.org/10.25135/rnp.67.18.01.207
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
    Dilfaraz Khan, Shah Iram Niaz, Kamran Tahir, Hidayat Ullah Khan, Muhammad Haroon, Shahid Ullah Khan, Syed Badshah, Shafiullah Khan, Muafia Jabeen and Liu Lan
PDF OF ARTICLE

ABSTRACT


Phytochemical investigation on pathogenic fungus Cylindrocarpon destructans isolated form Meconopsisgrandis plant led to the isolation of two new isochromene derivatives namely, 6,8-dimethoxy-3-methyl-3,4-dihydrobenzoisochromene-4,9,10-triol (1) and 3,5,6-trihydroxy-4-methylbenzoisochromene-9,11-dione (2) along with four known compounds (3-6). The structures of these compounds were elucidated by 1D and 2D NMR and mass spectroscopic data analysis. The isolated compounds were evaluated for cytotoxic activity. The compounds 1-4 showed good inhibition against the growth of cell lines MCF-7 and PC-3. Compounds 5-6 showed minimum inhibitory effect of cancerous cell lines growth.

KEYWORDS
  • Pathogenic fungus
  • Cylindrocarpon destructans
  • Meconopsis grandis
  • cytotoxic activity

SUPPORTING INFORMATION


Supporting Information
Download File 67-RNP-1801-207-SI.pdf (1.48 MB)