JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: May 05,2019
PAGES
p.1 - 8
DOI ADDRESS
http://doi.org/10.25135/rnp.128.19.02.1181
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Parinuch Chumkaew
  • Passakorn Teerapongpisan
  • Jaraslak Pechwang
  • Theera Srisawat
PDF OF ARTICLE

ABSTRACT


Two new oxoprotoberberine alkaloids, amocurine A and B (1 and 2), a new aporphine alkaloid, amocurine C (3), along with three known compounds (4-6) were isolated from the roots of Amoora cucullata. Their structures were determined by analysis of spectroscopic data. The isolated compounds were evaluated for their antiproliferative activity against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer). Compounds 3 showed the most potent activities against KB and MCF-7 cell lines with IC50 values 3.5 and 4.2 mM, respectively.

KEYWORDS
  • Oxoprotoberberine
  • Aporphine
  • Antiproliferative activity
  • Amoora cucullata

SUPPORTING INFORMATION


Supporting Information
Download File 128-RNP-1902-1181-SI.doc (3.8 MB)