JOURNAL 1775


Records of Natural Products
VOLUME & ISSUE
Available Online: September 26,2020
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.200.20.08.1775
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Shouhei Miyazaki
  • Hirotaka Oikawa
  • Hideo Takekoshi
  • Masako Hoshizaki
  • Masato Ogata
  • Takahiko Fujikawa
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Acanthopanax senticosus HARMS (ASH), a traditional Chinese herbal medicine, has been used to treat arthralgi, muscle weakness of the lower body, hypertension, and impotence. ASH was also reported to increase resistance to stress and fatigue. Recently, the efficacy of ASH against depression and stress-induced gastric ulcer was demonstrated in a rodent model. Previously, we also reported that ASH exerted anxiolytic effects and modulated autonomic nervous system activity under stress. However, no research has examined the anxiolytic effects of isofraxidin and syringin, two constituents of ASH. Thus, we investigated the anxiolytic constituents of ASH. The rats were administered distilled water, isofraxidin or syringin for 1 week. Autonomic nervous system activity was estimated using heart rate variability and anxiety behavior in the improved elevated beam walking (IEBW) test. The syringin increased the time spent in the open arm in the IEBW test. The syringin blocked the significant decrease in normalized high-frequency power, indicative of parasympathetic nervous system activity, in the IEBW test. The isofraxidin exerted no significant effects on behavior and autonomic nervous system activity. These results indicated that syringin partially contributes to the anxiolytic and autonomic nervous system-modulating effects of ASH.

KEYWORDS
  • Acanthopanax senticosus
  • isofraxidin
  • syringin
  • anxiolytics
  • autonomic nervous

SUPPORTING INFORMATION


Supporting Information
Download File 200-RNP-2008-1775-SI.pdf (132.99 KB)