JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: February 11,2019
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.119.18.09.940
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Meng-Yuan Jiang
  • Chun-Tao Yang
  • Xiao-Yun Pu
  • Guangmiao Fu
  • Wei Wang
  • Yu-Xiao Li
  • Lei Feng
  • Zhi-Rui Niu
  • Jian-Lin Tan
  • Xiang-Zhong Huang
  • 1 -
  • 2 - Yunnan Minzu University
  • 3 - Yunnan Minzu University
  • 4 - Yunnan Minzu University
  • 5 - Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministr
  • 6 - Yunnan Minzu University
  • 7 - Yunnan Minzu University
  • 8 - Yunnan Institute of Product Quality Supervision & Inspection (Nationnal Agricultural and Sideline Pr
  • 9 - Yunnan Institute of Product Quality Supervision & Inspection (Nationnal Agricultural and Sideline Pr
  • 10 - Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministr
PDF OF ARTICLE

ABSTRACT


A new polyacetylene, heptadeca-8,16-dien-4,6-diyn-3,l0-diol (1) along with four known polyacetylenes, 1,2-dihydrodendroarboreol B (2), heptadeca-1,8-dien-4,6-diyn-3,l0-diol (3), 3R, 8S-falcarindiol (4) and 3R,8R-dehydrofalcarindiol (5) were isolated from the ethanol extract of Aralia dumetorum. The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectrums and by comparison of the spectroscopic data with those reported for structurally related compounds. The α-glucosidase inhibitory activity of compounds 1-5 was evaluated using α-glucosidase inhibitory assay, in which all compounds displayed good inhibitory activity with IC50 values ranging from 4.2 ~ 36.2 μM..

KEYWORDS
  • Araliaceae
  • Aralia dumetorum
  • polyacetylenic compound
  • α-glucosidase inhibitor

SUPPORTING INFORMATION


Supporting Information
Download File 119-RNP-1809-940-SI.pdf (803.78 KB)