Three New Polyketides from the Insect-Associated Fungus Letendraea sp. 5XNZ4-2

Original Article

JOURNAL 1786

Records of Natural Products
VOLUME & ISSUE
Available Online: October 27,2020
PAGES
p.1 - 7
DOI ADDRESS
http://doi.org/10.25135/rnp.206.20.08.1786
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Yan Xu
  • Nanyan Fu
  • Wanjing Ding
  • Pinmei Wang
  • Jinzhong Xu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Chemical investigation of the EtOAc extract of an insect-associated fungus Letendraea sp. 5XNZ4-2 cultured in Potato Dextrose Broth (1/2 PDB) medium lead to the isolation of three new polyketides, named letendronol D (1), phomopsiketones H-I (2-3). The structures of new compounds were elucidated by the analysis of HRESIMS and NMR spectroscopic data, and the absolute configurations were determined by modified Mosher’s method, ECD calculation and single-crystal X-ray diffraction. Cytotoxicity and antibacterial activities of 1 were assayed and regrettably 1 didn’t display any cytotoxicity and antibacterial activity. 3 was the first phomopsiketone derivative obtaining the lactone.

 KEYWORDS
  • polyketides
  • insect-associated fungus
  • Letendraea sp.

SUPPORTING INFORMATION

Supporting Information
Download File 206-RNP-2008-1786-SI.pdf (4.08 MB)