Records of Natural Products
A scientific open acces journal in the field of natural products.
Records of Natural ProductsA scientific open acces journal in the field of natural products.
NF-κB Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer
This study aims to investigate the effects of co-administration of nano-Curcumin on anticancer effect of nano-Pirarubicin considering the fact that the clinical use of Pirarubicin and other anthracyclines has been limited by development of multidrug resistance (MDR) and based on previous data which have shown that Curcumin can down-regulate MDR proteins and suppress the activity of Nuclear factor-kappa B (NF-κB) a protein involved in chemoresistance. Nano micellar formulations of both Curcumin and Pirarubicin were separately synthesized using 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-[poly(ethylene glycol); PEG MW 2,000] (DSPE-PEG2000). The produced sterically stabilized micelles (SSM) are very well known drug delivery systems in terms of their enhanced efficacy and good toxicity profile. We measured the differences of NF-κB levels in two different situations: when Pirarubicin is used alone and when it is co-administered with Curcumin. This study showed that co-administration of SSM-Curcumin (CSSM) and SSM-Pirarubicin (PSSM) with size of 12.81 nm enhances the efficacy of Pirarubicin by suppressing P65, an NF-κB subunit. Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.DOI http://doi.org/10.25135/rnp.126.96.36.1994 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Curcumin pirarubicin nanoparticles NF-κB breast cancer Available online: January 19, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
A New Ursane-Type Triterpene from the Roots of Salvia miltiorrhiza Bunge
Danshen (Salvia miltiorrhiza) is a one of the most well-known medicinal herbs in the Oriental medicine for treatment of certain cardiovascular disoders. Our current research on triterpenoid component in danshen roots led to the isolation of a new highly hydroxylated ursane-type triterpene, urs-12,20(30)-dien-3β,7β,24-triol-28-oic acid (2) and one known triterpene, epiasiatic acid (1). Their structures were elucidated on the basis of extensive spectroscopic analyses including NMR and MS spectra and comparison with literature data. The new compound 2 showed medium activity against HL-60 cells with the IC50 value of 16.3 μM. The obtained results of unique bioactive triterpenes from danshen contributed not only to its phytochemical profile associated with chemotaxanomy but also to biological evidence of the title plant.DOI http://doi.org/10.25135/rnp.97.18.07.330 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Danshen Salvia miltiorrhiza Lamiaceae triterpene Available online: January 19, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Biodiversity and Secondary Metabolites of Marine Sponges from Turkey
Turkey is surrounded by the Black Sea, the Aegean Sea and the Mediterranean sea, comprising a rich source of marine biodiversity. Among all marine species, sponges with a wide range of secondary metabolites are an important potential for drug discovery. There are many studies on sponges and their secondary metabolites, but not enough study about Turkish sponges. The present review gives an overview of the current research trends on secondary metabolites from Turkish marine sponges and some of their biological activities. Until today alkaloids, steroids and phenolic compounds have been isolated and determined from Turkish sponges. To our knowledge, this is the first review about Turkish sponges. Furthermore, we have tried to introduce our Marine Herbarium of Ankara University Pharmacy Faculty (MAP).DOI http://doi.org/10.25135/rnp.118.18.07.340 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Bioactivity biodiversity secondary metabolite sponge Available online: January 14, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
New Xanthone from Millettia pachyloba Drake
A new xanthone, 1,7-dihydroxy-2,3,5,6-tetramethoxyxanthone (1), together with eight known compounds including one xanthone (2) and seven isoflavones (3-9) has been isolated from the leaves of Millettia pachyloba. This is the first report on the isolation of xanthone from the genus Millettia. The structure of the compound 1 was elucidated on the basis of spectroscopic data interpretation, including 1D and 2D NMR and HREIMS. Compound 1 exhibited weak cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7 and SW480.DOI http://doi.org/10.25135/rnp.188.8.131.520 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Millettia pachyloba Drake Leguminosae xanthone Available online: January 10, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.